After 3 days of dosing, the dose may be increased to 300 mg per day, given as 100 mg 3 times daily, with at least 6 hours between successive doses. Solriamfetol, sold under the brand name Sunosi, is a wakefulness-promoting medication used in the treatment of excessive sleepiness related to narcolepsy and sleep apnea. Common side effects reported in studies of major depressive disorder include weight loss, loss of appetite, dry mouth, skin rash, sweating, ringing in the ears, shakiness. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Furthermore, bupropion. Increased or irregular heart beat. tremors; fast heartbeats; blurred vision; nausea, vomiting, diarrhea, constipation; changes in weight or appetite; dry mouth, yawning; increased sweating; or. Bupropion is a cytochrome p450 2D6 inhibitor and care must be taken when coprescribing with drugs cleared by this enzyme and when coprescribing with drugs that lower seizure threshold. Smoking cessation, usually called quitting smoking or stopping smoking, is the process of discontinuing tobacco smoking. Bupropion is not a controlled substance. 6 The median dose associated with seizures is about 4. Psychological symptoms Mood swings, agitation, anxiety, mania, andor depression. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. You may be more likely to experience side effects, including a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme. Bupropion hydrochloride is an antidepressant drug belonging to the aminoketone class first introduced in 1985. Bupropion is far more dangerous than other commonly used antidepressants (especially selective serotonin-release inhibitors). These results suggest that bupropion improves attention without affecting impulsive behavior in healthy adults. Legal status. Estimated number of patients in the United States (2020) 5,801,282. A norepinephrinedopamine reuptake inhibitor (NDRI) is a drug used for the treatment of clinical depression, attention deficit hyperactivity disorder (ADHD), narcolepsy, and the management of Parkinson's disease. It contains a buspirone (1). 1 Bupropion har flere egenskaber, der adskiller det fra andre antidepressiva det for&229;rsager normalt ikke seksuel dysfunktion; 2 det er ikke forbundet med v&230;gt&248;gning 2 og s&248;vnighed , og det er mere effektivt end SSRI til at. , high blood pressure, Type 2 diabetes, or high cholesterol) 515. It is also spelled phenethylline and fenetylline (); other names for it are amphetamin oethyl theophylline and amfetyline. Some of the more commonly reported side effects with tricyclic antidepressants include A drop-in blood pressure when moving from a sitting to standing position. It is useful in patients resistant to other agents as well as in patients with atypical depression. , 2004). Bupropion is effective for major depressive disorder (MDD) and seems to be a reasonable choice to address our patients mood symptoms 6 . Bupropion was rarely prescribed when the presence of comorbid anxiety disorders or symptoms reflecting central nervous system activation influenced antidepressant selection. Identify the need for solvent substitution with green solvents 3. Headache, dry mouth, nausea, sweating, increased or irregular heartbeat. It is a primary medication for ADHD (e. Infectiology, hematology. Generic names methylphenidate (METH il FEN i date) or dexmethylphenidate (DEX meth il FEN i date) Methylphenidate extended release CD Capsules 10 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg; Caplets 18 mg, 27 mg, 36 mg, 54 mg. Can be used in patients who are receiving 300 mgday of another bupropion formulation for at least 2 weeks, and require a dosage of 450 mgday (2. Doses above 300 mg of bupropion hydrochloride extended-release were not assessed in the SAD trials. Bupropion XL (Wellbutrin XL) is a moderately priced drug used to treat depression. This article appeared on Wikipedia&x27;s Main Page as Today&x27;s featured article on December 21, 2007. Yes, certain side effects of Wellbutrin are dose dependent. Increased or irregular heart beat. Met criteria in pooled data set. The most common side effects of WELLBUTRIN are nervousness, constipation, trouble sleeping, dry mouth, headache, nausea, vomiting, and shakiness (tremor). Lexapro (escitalopram) - an antidepressant of the SSRI class. Among patients in whom augmentation or a switch to. Some side effects may occur that usually do not need medical attention. In addition, bupropion is used to as an aid in smoking cessation treatment. In addition to being used for depression, bupropion is also used to help people quit smoking. The dose of bupropion is 150 mg once a day for 6 days, increasing to 150 mg twice a day (doses at least 8 hours apart) for a total of 79 weeks. The below tables contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepines, also listed, along with their trade names and primary uses. Delayed onset bupropion-associated. The lower dose of 150 mg once a day should be continued if the person Is elderly. Sir Bupropion is an antidepressant originally approved by the U. About Wikipedia; Contact us; Donate; Contribute Help; Learn to edit; Community portal; Recent changes; Upload file; Languages. Bupropion Pill Images. It is probably the main contributor to the stimulant effect of Catha edulis, also known as khat. Yes it can, but the rate of anxiety as a side effect to bupropion are about the same as that of other antidepressants, according to several analyses of controlled FDA-registration trials. Bupropion comes as immediate-release (IR), sustained-release (SR), and extended-release (ER or XL) tablets. It is formed from bupropion by the liver enzyme CYP2B6 during first-pass metabolism. Do not initiate treatment with FORFIVO XL. For some men, taking sildenafil (Viagra) or tadalafil (Cialis) can alleviate SSRI-induced erectile dysfunction. Wellbutrin (bupropion) and Lexapro (escitalopram) are two brand-name, orally administered medications for treating anxiety and major depressive disorder (MDD). If youre experiencing certain side effects from one type of antidepressant, switching to another may help relieve them. The SR and XL tablets come in both brand-name and generic. However, studies have shown that a small number of people (especially people younger than 25) who take. The two doses should always be separated by at least eight hours. Don&x27;t take bupropion past 5pm to avoid trouble sleeping. For deficiencies in reward valuation (emotional blunting), dopamine receptor agonists, methylphenidate and bupropion may be used. Research suggests that taking bupropion during pregnancy might be linked with a small risk of miscarriage or heart defects. Bupropion is an antidepressant used to treat major depressive disorder (MDD) and seasonal affective disorder (SAD). By doing this, dextromethorphan lasts longer in your body. Nearly one out of 10 prescriptions among psychotherapeutics was attributed to bupropion in 2018 . Yes, certain side effects of Wellbutrin are dose dependent. Taking Wellbutrin can increase the risk of suicidal thoughts and behaviors, so close monitoring for these side effects is important. CrossRef Google Scholar PubMed. 1See more. While similar, both drugs contain key differences regarding specifically approved indications and dosing regimens. Dosing above 300 mg per day may be accomplished using the 75- or 100-mg. Dextromethorphanbupropion (DXMBUP), sold under the brand name Auvelity, is a combination medication for the treatment of major depressive disorder (MDD). 4 at dosages between 300 to 450 mgday, but increases almost tenfold between 450. A method for estimating the probability of adverse drug reactions. 15; p 0. It is used to treat major depressive disorder, anxiety disorders, and difficulties with sleep. 2 It is used to treat opioid use disorder, and reduces the mortality of opioid use disorder by 50 (by reducing the risk of overdose on full-agonist opioids such as. Incidence rates for the 4 outcomes were elevated among GLP-1 agonists compared with bupropion-naltrexone users. You may be more likely to experience side effects, including a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme. Bupropion, approved for. The skeletal structure of norepinephrine The skeletal structure of dopamine. Antidepressants can help prevent suicidal. 4 CONTRAINDICATIONS. Bupropion is an atypical antidepressant which inhibits the reuptake of noradrenaline and dopamine and has been used for treatment of MDD. It decreases body weight in patients with diabetes, but its effect on diabetic. Objective To conduct a systematic review and meta-analysis assessing efficacy and tolerability of combination therapy. Cytochrome P450 2C19 (abbreviated CYP2C19) is an enzyme protein. Depression is considered to be the worlds most common mental health problem, and one of the major causes of debilitation. We would like to show you a description here but the site won&x27;t allow us. (three times per day), bupropion SR (sustained-release) 150 mg b. Common side effects include dry mouth, feeling faint, vomiting, and headache. It may be 4 weeks before you feel the benefit and you will take the drug for several months. The seizures stopped when the person who was breastfeeding stopped taking. If you have trouble swallowing, talk with your doctor. Nov 1, 2023 Bupropion may cause some people to be agitated, irritable, or display other abnormal behaviors. Antidepressants can help prevent suicidal thoughtsattempts and provide other important benefits. Bupropion, which affects both norepinephrine and dopamine, can sometimes improve sexual response. Relatedsimilar drugs Trintellix, sertraline, trazodone, Lexapro, Zoloft, Cymbalta, Wellbutrin Warnings. File history. 2 It is used to treat opioid use disorder, and reduces the mortality of opioid use disorder by 50 (by reducing the risk of overdose on full-agonist opioids such as. The list is ordered alphabetically according to the condition or conditions, then by the generic name of each medication. Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. Serotonin, the neurotransmitter that is involved in the mechanism of action of SSRIs. 15; p 0. Although bupropion shares some structural and pharmacologic properties with amphetamine, early research suggested the drug did not produce any psychostimulant effects. Advise the patient to read the FDA-approved patient labeling (Medication Guide). Across cohorts, the most frequent adverse events by treatment group were nausea (varenicline, 25 511 of 2016 participants), insomnia (bupropion, 12 245 of 2006 participants. These side effects may go away during treatment as your body adjusts to the medicine. In placebo-controlled clinical studies, the specific adverse events that led to discontinuation in at least 1 of patients treated with either 300 mg or 400 mg per day of Wellbutrin SR (R)included rash, nausea, agitation, and migraine. This analgesic -related article is a stub. 8 points in the 37 people. Wellbutrin withdrawal symptoms aren&39;t common, but those who experience them may. Although currently available antidepressants increase monoamine levels soon after the start of treatment, therapeutic benefits are often delayed by several weeks and the majority of patients with major depressive disorder fail to achieve an adequate response to first- or second-line therapies target. Initially 150 mg daily for 6 days, then 150 mg twice daily (max. Bupropion is a relatively weak inhibitor of the neuronal reuptake of norepinephrine and dopamine and does not inhibit monoamine oxidase or the reuptake. Try to take bupropion at the same time every day. Bupropion hydrochloride tablets USP are indicated for the treatment of major depressive disorder (MDD), as defined by the Diagnostic and Statistical Manual (DSM). Delayed onset bupropion-associated. ; Moderate inhibitor being one that causes at least a 2-fold. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Immediate release 100-150mg PO 2-4 times daily; Sustained release 150mg PO 1-2 times daily; Pediatric Dosing. Mixing Wellbutrin and alcohol can increase a person&x27;s risk of side effects, including seizures. It is used to treat major depressive disorder, generalized anxiety disorder, panic disorder, and social anxiety disorder. They are commonly used as anesthetics for animals and humans; the state of anesthesia they induce is referred to as dissociative anesthesia. Bupropion is an antidepressant used to treat a variety of conditions, including depression, other mentalmood disorders, and smoking cessation. Size of this PNG preview of this SVG file 512 242 pixels. Threohydrobupropion (developmental code names BW 494, BW A494U) is a substituted amphetamine derivative specifically a -hydroxyamphetamine and a major active metabolite of the antidepressant drug bupropion (Wellbutrin). It might be an option for pregnant people who haven&39;t gotten enough relief from other medicines. dry mouth. Bupropion is a commonly prescribed antidepressant that acts as a norepinephrinedopamine reuptake inhibitor (NDRI). Aplenzin (bupropion hydrobromide) isn&x27;t FDA-approved to help you quit smoking, but this medication contains the same active ingredient as the smoking cessation medication, bupropion HCl sustained-release. Your doctor will start you at a low dose and gradually increase it over time until the maximum efficacy has been achieved. 65 for the most common version, by using a GoodRx coupon. Leukopenia (from Greek (leukos) 'white', and (penia) 'deficiency') is a decrease in the number of leukocytes (WBC). These problems have happened in people with and without a history of mental or mood problems. Bupropion (Aplenzin, Wellbutrin XL) se utiliza para tratar el trastorno afectivo temporal (SAD, por sus siglas en ingl&233;s); episodios de depresi&243;n que ocurren al mismo tiempo. Food and Drug Administration (FDA) has approved Forfivo XL, for patients with Major Depressive Disorder. Wellbutrin is a very powerful drug and so is THC and its family metabolites. Mixing Wellbutrin and alcohol can increase a person&x27;s risk of side effects, including seizures. Recommended dosage. Among patients in whom augmentation or a switch to. I would presume that the reason people might associate weight gain with Wellbutrin is because the tricyclics and to some extent the SSRIs (i. com is the most popular, comprehensive and up-to-date source of drug information online. But too much serotonin causes signs and symptoms that can range from mild (shivering and diarrhea) to severe (muscle rigidity, fever and seizures). Bupropion comes as immediate-release (IR), sustained-release (SR), and extended-release (ER or XL) tablets. Bupropion Hydrochloride contains NLT 98. 70, which is 70 off the average retail price of 38. Bupropion hydrochloride is the active drug in the SR and XL forms of bupropion hydrochloride ER oral tablets. Wellbutrin is the brand name for the antidepressant drug bupropion. Tablet dextromethorphan hydrobromide 45 mg - bupropion hydrochloride 105 mg. With these additions, a total of three pharmaceutical approaches for smoking cessation are now present on the WHO EML. The list is not exhaustive and not all drugs are used regularly in all countries. Bupropion is an antidepressant used to treat a variety of conditions, including depression, other mentalmood disorders, and smoking cessation. Serious allergic reactions itchy skin, hives, swelling of lips, tongue, throat, shortness of breath, chest pain. The recommended starting dose is 200 mg per day, given as 100 mg twice daily. Probiotics Might Help Ward Off COVID-19. Generic name bupropion. Bupropion is an antidepressant that is FDA-approved to treat depression; however, it has shown some benefits for ADHD. Generic name Dextromethorphan and bupropion (deks troe meth OR fan & byoo PRO pee on) Brand names Auvelity ER. Weight loss - Bupropion may cause decrease in appetite, leading to weight loss. From Wikimedia Commons, the free media repository. The U. Drinking alcohol while taking bupropion may raise your risk for serious side effects. You should space out Wellbutrin doses by 6 hours and Wellbutrin SR doses by 8 hours. Nov 1, 2023 For oral dosage form (tablets) For depression AdultsAt first, 100 milligrams (mg) two times per day. Bupropion comes in 150 mg pills. Antidepressants can help. It is sold under the brand names Barhemsys 9 (as an antiemetic) and Solian, Socian, Deniban and. ozanimod increases toxicity of bupropion by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. It is a chemical derivative of diethylpropion, an amphetamine-like substance used as an anorectic. It is chemically similar to the cathinone compounds found in the khat plant of eastern Africa. People may experience side effects when taking Wellbutrin. Wellbutrin is a brand name for the medication bupropion, which is used to treat major depressive disorder (MDD) as well as seasonal affective disorder (SAD), per Medical News Today. WELLBUTRIN tablets, 100 mg of bupropion hydrochloride, are red, round, biconvex tablets printed with "WELLBUTRIN 100" in bottles of 100 (NDC 0173-0178-55). English Steady-state plasma levels of bupropion (ngmL) with bupropion IR (immediate-release) 100 mg t. Bupropion group did not meet criteria for response in study 1 or study 2. Naltrexonebupropion produces clinically significant weight loss when combined with a diet and exercise program. Wellbutrin (bupropion hydrochloride) is an antidepressant drug. 00, which is 70 off the average retail price of 20. Bupropion lowers the seizure threshold, even at therapeutic doses of 150450 mgd. Mar 19, 2019 Therapeutic doses of bupropion (150-300 mg daily) are generally well tolerated with the most common side effects being dry mouth and insomnia. 2013 were included. Antidepressants can help. This prescription is often used. Bupropion is a unique antidepressant with FDA-approved indications for major depressive disorder 1-32, seasonal affective disorder 1,2, smoking cessation 4, and as an adjunct to diet and exercise for chronic weight management in adult patients with BMI >30 kgm2 when co-formulated with naltrexone. prometheus remote write protobuf, craigslist santa barbara ca
Phenethylamine is a primary amine, the amino-group being attached to a benzene ring through a two-carbon, or ethyl group. . Bupropion wiki
The COR-Diabetes study evaluated overweight and obese patients with type-2 diabetes. Sep 24, 2023 Applies to bupropion oral tablet, oral tablet extended release. Patients who stayed on the medication had an average of 11 greater reduction in depressive symptoms than placebo in an FDA approval trial. This combination has not been linked to serum enzyme elevations or clinically apparent liver injury, but has had limited general use. Bupropion, also sold as Wellbutrin or Zyban, is an antidepressant. O bupropiom ou bupropiona (nomes comerciais Wellbutrin, Zyban, Bup, entre outros) &233; um f&225;rmaco utilizado principalmente para o tratamento da depress&227;o e do tabagismo. Mixing Wellbutrin and alcohol can increase a person&x27;s risk of side effects, including seizures. However, it has a higher chance of causing seizures than other. Another 3 placebo-controlled trials investigated bupropion XL for the prevention of a relapse into seasonal affective disorder (SAD) (treatment duration 12 to 29 weeks). Call your doctor for medical advice about side effects. The dose may be increased up to 450mg per day, divided into 3-4 times. We found low-quality evidence that bupropion decreased the severity of ADHD symptoms and moderately increased the proportion of participants achieving a significant clinical improvement in ADHD symptoms. Bupropion is. Bupropion typically is taken orally in the form of bupropion hydrochloride. 1 Patients who stayed on the medication had an average of 11 greater reduction in depressive symptoms than placebo in. 3 Bupropion has been used to. The effects of bupropion on blood pressure and heart rate were evaluated in a double-blind, placebo-controlled study of community volunteers with untreated mild (stage 1) hypertension (systolic blood pressure SBP, 140-159 mm Hg, andor diastolic blood pressure, 90-99 mm Hg). Los efectos adversos comunes del bupropi&243;n con la mayor diferencia con el placebo son sequedad de boca, n&225;useas, estre&241;imiento, insomnio, ansiedad, temblores y sudoraci&243;n. renal dysfunction. Amoxapine - Wikipedia. Our cohort included 4144 liraglutide, 613 semaglutide, and 654 bupropion-naltrexone users. In placebo-controlled clinical studies, the specific adverse events that led to discontinuation in at least 1 of patients treated with either 300 mg or 400 mg per day of Wellbutrin SR (R)included rash, nausea, agitation, and migraine. Brand names Wellbutrin XL, Wellbutrin SR, Aplenzin, Forfivo XL Budeprion Budeprion SR. One factor that makes Wellbutrin especially unique among antidepressants is that it doesn't tend to affect sexual function or reduce libido, and may. It is also used to help people quit smoking. Bupropion is an antidepressant used to treat a variety of conditions, including depression, other mentalmood disorders, and smoking cessation. However, early reports of seizures with bupropion therapy in patients with bulimia limited its use. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines. Please review before taking this medication. Bupropion hydrochloride is marketed under the following names Wellbutrin. Bupropion je inn ltka s lkrenskm vyuitm, kter je pouvna pedevm jako antidepresivum a dle tak pi odvykn kouen. Dec 14, 2023 The usual adult target dose for bupropion hydrochloride extended-release (SR) tablets is 300 mgday, given as 150 mg twice daily. , sold under the brand name among others, is a tricyclic antidepressant (TCA). It comes as an immediate-release, sustained-release, or extended-release tablet that is taken orally. TCAs were discovered in the early 1950s and were marketed later in the decade. It is important to take the medication exactly as directed to minimize adverse effects. There are 8 disease interactions with bupropion which include suicidality. 2 Dosage for Major Depressive Disorder (MDD) The recommended starting dose for MDD is 150 mg once daily in the morning. 8 per 1000. 055 was determined to be 53 kJ mol (-1. 6 It is primarily used to treat major depressive. Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control excess body fat. Bupropion was first synthesized by Burroughs Research in 1966, and patented by BurroughsWellcome (now GlaxoSmithKline) in 1974. Nausea and vomiting. Lisdexamfetamine, most commonly sold under the brand name Vyvanse (in the United States and Canada) and Elvanse (in most European countries) among others, is a stimulant medication that is used to treat attention deficit hyperactivity disorder (ADHD) in children and adults, and for moderate-to-severe binge eating disorder in adults. It is taken by mouth, available commercially as an oxalate salt exclusively. Bupropion (Wellbutrin) is an antidepressant medication that affects chemicals within the brain that nerves use to send messages to each other. Bupropion is the active ingredient in Wellbutrin and Zyban, Auvelity contains bupropion and dextromethorphan, and Contrave contains bupropion and naltrexone. The pharmacology of antidepressants is not entirely clear. Mehanizem antidepresivnega delovanja bupropiona ni znan, domnevno pa je povezan z noradrenerginimi inali dopaminerginimi mehanizmi. 1 2 3 Other terms such as cutting, self-injury, and self-mutilation have been used for any self-harming behavior regardless of suicidal intent. Historical developments. Bupropion is an antidepressant used to treat a variety of conditions, including depression, other mentalmood disorders, and smoking cessation. It is a member of the CYP2C subfamily of the cytochrome P450 mixed-function oxidase system. This combination has not been linked to serum enzyme elevations or clinically apparent liver injury, but has had limited general use. 8 points in the 37 people. It is taken by mouth. Before 2000, the drug was referred to as amfebutamone. slow or irregular heartbeat. Dextromethorphanbupropion (DXMBUP), sold under the brand name Auvelity, is a combination medication for the treatment of major depressive disorder (MDD). 1 They act by antagonizing the 2 -adrenergic receptor and certain serotonin receptors such as 5-HT 2A and 5-HT 2C, 1. 1 However, clinical experience and an increasing number of case reports describe bupropion abuse, 2. The brand of bupropion is used to help people stop smoking by reducing cravings and other. Hydroxyzine is an antihistamine. In mild to moderate toxic doses it produces agitation, hallucination. 8), and. The purpose of the current study was to examine whether, in a controlled study, bupropion would improve the symptoms of RLS, or at least not exacerbate them. After receiving citalopram (level 1), participants without sufficient symptomatic benefit are eligible for randomization to level 2 treatments, which entail four switch options (sertraline, bupropion, venlafaxine, cognitive therapy) and three citalopram augment options (bupropion, buspirone, cognitive therapy). If no effect is seen after 7 weeks, discontinue treatment with bupropion. None of the patients experienced adverse effects. It is thought to work by modulating glutamatergic neurotransmission. In humans, it is the CYP2C19 gene that encodes the. Auvelity works in several different ways because it contains two different ingredients, dextromethorphan and bupropion, although the exact way it works. Wellbutrin XL 150 Mg 24 Hr Tablet, Extended Release Antidepressant Dopamine Norepinephrine Reuptake Inhibitors - Uses, Side Effects, and More Generic Name(S) bupropion HCl. It is now illegal in most countries and is produced primarily for illicit use. Bupropion-naltrexone (Contrave) Combines an antidepressant with a drug that blocks the effects of opioids. It comes as an immediate-release, sustained-release, or extended-release tablet that is taken orally. In addition, bupropion has reportedly been used in the treatment of chronic fatigue syndrome and Crohn's disease, with equivocal results. Bupropion, er et atypisk antidepressivum, der primrt bruges til at behandle svr depression, og til at sttte rygestop. In a study comparing 14-day dosing with WELLBUTRIN XL Tablets 300 mg once daily to the immediate-release formulation of bupropion at 100 mg 3 times daily, equivalence was. Amphetamine and its substituted derivatives contain a CH 3 group at the alpha-position (R). Bupropion therapy can be associated with transient, usually asymptomatic elevations in serum aminotransferase levels and has been linked to rare instances of clinically apparent acute liver injury. Atomoxetine works in the brain to increase attention and decrease restlessness in people who are hyperactive, have problems with. Bupropion hydrochloride extended-release tablets (XL) are contraindicated in patients with seizure disorder. BUPROPION treats depression. Bupropion, also sold as Wellbutrin or Zyban, is an antidepressant. Latuda (lurasidone) an atypical antipsychotic. They are named after their chemical structure, which contains three rings of atoms. Bupropion, sold under the brand name Wellbutrin among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking. . venice fl yard sales